My biggest side effect was weight gain and it causes more depression. The problem is once you stop taking the medication the weight doesn't go either, so it's a catch 22 situation. I have a friend who doesn't want to take her medication because of the weight she has gained and I can understand that. It's not even about how much you eat, but it just happens. I didn't eat more, and at times I starved myself to lose the weight and it still didn't shift. I lost some eventually when I stopped the medication, but it took a year to get back to normal and it was hard mentally. There were other side effects too, one medication made me so emotional and another made me drowsy.